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CRCHUM Immunoregulation Laboratory

By Heena Mehta, Ph.D, and Marika Sarfati, MD Ph.D

The “initial trigger” for scleroderma is still unknown, but it is now thought to be an “insult” to the immune system leading to dysregulation of immune pathways, and the cascade of events that lead to clinical manifestations.

Key interests of the research team at CRCHUM (Research Centre of the University of Montreal Health Centre) include study of immune cell populations such as T cells, and dendritic cells, which are the sentinels of the body’s defence system, as well as their interactions at barrier sites such as skin, lungs, and gut.

In recent years, the rapid advancement of technology available to immunologists to study cells in affected tissues at a single-cell level, and concomitant development of tools for analysis of high-dimensional data make it an exciting time to be studying the immunopathology of scleroderma.

Researcher profiles

Current research project summaries

Here, we highlight some milestones we have reached with generous support from various scleroderma associations in Canada including Sclérodermie Québec, Scleroderma Society of Ontario, and Scleroderma Society of Canada.